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From: ScienceDaily (1:317/3)
To: All
Date: Mon, 22.03.21 22:30
Uniform drying time for goldenseal to en
Uniform drying time for goldenseal to enhance medicinal qualities of
forest herb

Date:
March 22, 2021
Source:
Penn State
Summary:
Developing a standardized drying protocol for goldenseal could lead
to more predictable health applications and outcomes by preserving
the alkaloids found in the plant, which is native to Appalachia,
according to researchers who conducted a new study of the medicinal
forest herb.



FULL STORY
==========================================================================
Developing a standardized drying protocol for goldenseal could lead
to more predictable health applications and outcomes by preserving the
alkaloids found in the plant, which is native to Appalachia, according
to Penn State researchers, who conducted a new study of the medicinal
forest herb.


==========================================================================
The roots and rhizomes of goldenseal -- Hydrastis canadensis -- have been
used for hundreds of years as a source of antimicrobials and compounds
to treat intestinal ailments, noted study co-author Eric Burkhart,
associate teaching professor, ecosystem science and management.

"Three alkaloids -- berberine, hydrastine and canadine -- are recognized
as the major bioactive constituents in goldenseal," said Burkhart, who
also is program director, Appalachian botany and ethnobotany, at Shaver's
Creek Environmental Center. "One important postharvest processing step
for goldenseal is drying.

However, before this study it was not known how drying temperature
influences the concentrations of these alkaloids." To investigate this
question, researchers removed goldenseal samples from three plant colonies
within a wild population located in central Pennsylvania.

Fourteen "ramets," or bunches, were harvested from each plot in early
April while plants were dormant.

Lead researcher Grady Zuiderveen, doctoral student in ecosystem science
and management, freeze-dried or air-dried goldenseal samples at six
temperatures, ranging from 80 to 130 degrees Fahrenheit, to determine
the relationship between drying temperature and alkaloid content in the
rhizome and roots.

In findings recently published in Hortscience, high performance liquid
chromatography analysis showed that berberine and hydrastine levels
were unaffected by drying temperature, while canadine levels decreased
as temperature increased. On average, the level of canadine dropped
by slightly more than half when samples were freeze-dried and fell by
nearly a third when dried at 130 F.

While canadine is the least abundant alkaloid of the three, it is known to
have key antibacterial properties, Zuiderveen pointed out, so developing
a more standardized drying protocol for goldenseal could lead to a more
predictable phytochemical profile.

"This work is important because canadine has been found to have
significant activity against numerous strains of bacteria, and in previous
research it was the only one of the three major alkaloids found to be
active against Pseudomonas aeruginosa and Staphylococcus aureus," he
said. "Also, canadine possesses significant antioxidant properties and
has been identified as effective at strengthening the immune system."
The Pennsylvania Department of Conservation and Natural Resources'
Wild Resources Conservation Program funded this research.

==========================================================================
Story Source: Materials provided by Penn_State. Original written by Jeff
Mulhollem. Note: Content may be edited for style and length.


==========================================================================
Journal Reference:
1. Grady H. Zuiderveen, Eric P. Burkhart, Joshua D. Lambert. Influence
of
Postharvest Drying Temperatures on Alkaloid Levels in Goldenseal
(Hydrastis canadensis L.Wink. HortScience, 2021; 56 (2): 242 DOI:
10.21273/ HORTSCI15500-20
==========================================================================

Link to news story:
https://www.sciencedaily.com/releases/2021/03/210322135230.htm

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